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Patil, P. A.
- Anti-inflammatory and Anti-ulcer Effects of Calotropis gigantea R.Br Flowers in Rodent
Abstract Views :598 |
PDF Views:696
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Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 183-190Abstract
Objective: To evaluate the chloroform extract of Calotropis gigantea flowers (CCGF) and ethanol extract of Calotropis gigantea flowers (ECGF) for their possible anti-inflammatory (AI) and anti-ulcer (AU) activities. Method: The anti-inflammatory effect of CCGF and ECGF (200mg/kg; p.o.) was investigated in carrageenan induced rat paw edema and cotton pellet induced granuloma model. The AU activity studied in pylorus ligation and aspirin induced gastric ulcers model. The aspirin and ranitidine were used as standards for AI and AU studies respectively. Results: The CCGF and ECGF significantly reduced rat paw edema (p > 0.05 to > 0.01) and dry weight granuloma (p > 0.01). Similarly, both extracts treated group were significantly (p > 0.01) protected from pyloric ligation and aspirin induced gastric ulcers. These effects were statistically significant. Conclusion: The results suggest that the CCGF and ECGF possess significant AI and AU activities. The observed effect may be due to the presence of protease like bioactive constituent.Keywords
Calotropis gigantea Flower, Anti-inflammatory, Anti-ulcer, Aspirin- Influence of Bryophyllum pinnatum (Lim.) Leaf Extract on Wound Healing in Albino Rats
Abstract Views :722 |
PDF Views:1120
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Journal of Natural Remedies, Vol 4, No 1 (2004), Pagination: 41-46Abstract
Objectives: To study the effect of Bryophyllum pinnatum (Lam.) leaf extracts viz. petroleum ether, alcohol and water on healing of excision, resutured incision and Dead space wound models in Albino rats. Materials and Method: Excision, resutured incision and dead space wound models were induced in albino rats of either sex under light ether anaesthesia. Control animals received normal saline orally and other groups received petroleum ether, alcohol and water extract orally for a period of 10 days. Doses for all the three extracts were selected based on the results of acute toxicity studies in mice. On tenth day after estimating the breaking strength of resutured incision wounds, animals were sacrificed. In the dead space wound models granulomas were removed for estimating the breaking strength. Quantification of granuloma tissue and their biochemical and histological aspects in control as well as treated groups were estimated. In excision wound model epithelization time was measured from day-0 (wounding day) till the day of scar falling off with no raw wound left behind. The shape and size of the scar was noted on the day of complete epithelization and were followed upto the 21st post wounding day. Results: All the three extracts viz. petroleum ether, alcohol and water showed significant increase in the breaking strength of incision wound as compared to control group (p<0.001). granuloma breaking strength and hydroxyproline content of granulation tissue in dead space wound model was significantly increased as compared to control group (p<0.001). Water extract showed significant increase in wound contraction and formation of scars on 17th post wounding day in excision wound model (p<0.001). Conclusion: The results of the present study indicate, that not only topical application of water extract hastened the healing process in excision wound model, but also all the three extracts administered orally, promoted the healing of resutured incision and dead space wounds, as indicated by increased breaking strength and hydroxyproline content of the granulation tissue, thereby justifying its use in traditional medicine.Keywords
Bryophyllum pinnatum (Lam.), Excision Wound Model, Incision Wound Model, Dead Space Wound Model, Wound Healing- Evaluation of Aqueous Extract of Pulp and Seeds of Moringa oleifera for Wound Healing in Albino Rats
Abstract Views :517 |
PDF Views:655
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Journal of Natural Remedies, Vol 4, No 2 (2004), Pagination: 145-149Abstract
Objective: To study the effect of aqueous extract of the dried pulp and seeds of Moringa oleifera on wound healing in albino rats. Materials and methods: The aqueous extract was studied at dose level of 300 mg/kg body weight using resutured incision; excision and dead space wound models in rats. Results: Significant increase in wound closure rate, skin-breaking strength, granuloma breaking strength, hydroxyproline content, granuloma dry weight and decrease in scar area was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results obtained, it may be concluded that the aqueous extract of Moringa oleifera has significant wound healing property. Also it can be concluded that these prohealing effects may be due to their high content of crude proteins, zinc and some anti-microbial component.Keywords
Moringa oleifera, Wound Healing, Aqueous Extract- Screening of Most Effective Nano Metal Between AgNP, CuNP and Ag-Cu NP's Synergistic by in Vitro Antibacterial Comparison
Abstract Views :215 |
PDF Views:0
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Affiliations
1 Dept. of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, IN
1 Dept. of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, IN
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Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 81-84Abstract
The metal nanoparticles like silver, copper have attracted much attention as potential antimicrobial agents. In order to trace out very effective antimicrobial therapy needs invitro comparison of these nanoparticles and Synergistic activity by combining these two molecules together for their commercial application. The present work concluded that CuNP are most potent antimicrobial agents in comparison to AgNP and synergistic activity.Keywords
Antibacterial Properties, Coppernanoparticles, Silver Nanoparticles, Synergistic Antimicrobial.- Screening of most Effective Nanometal between AgNP, CuNP and Ag-Cu NPs Synergistic by Invitro Antibacterial Comparison
Abstract Views :182 |
PDF Views:9
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1 Dept. of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, IN
1 Dept. of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, IN
Source
Nano Science & Nano Technology: An Indian Journal, Vol 10, No 1 (2016), Pagination: 36-39Abstract
The metal nanoparticles like silver, copper have attracted much attention as potential antimicrobial agents. In order to trace out very effective antimicrobial therapy needs invitro comparison of these nanoparticles and Synergistic activity by combining these two molecules together for their commercial application. The present work concluded that CuNP are most potent antimicrobial agents in comparison to AgNP and synergistic activity.
Keywords
Antibacterial Properties, Coppernanoparticles, Silver Nanoparticles, Synergistic Antimicrobial.- Nanotechnology, Nanodevice Drug Delivery System:A Review
Abstract Views :273 |
PDF Views:10
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Affiliations
1 Annasaheb Dange College of Pharmacy, Ashta, Sangli. Maharashtra, 416301, IN
2 Rajarambapu Colleges of Pharmacy, Kasegaon, Sangli. Maharashtra, 416301, IN
1 Annasaheb Dange College of Pharmacy, Ashta, Sangli. Maharashtra, 416301, IN
2 Rajarambapu Colleges of Pharmacy, Kasegaon, Sangli. Maharashtra, 416301, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 2 (2017), Pagination: 63-71Abstract
Nanotechnology is a promising area in the drug delivery system, with many possible applications of nano device. "Nanotechnology" is emerging new technological development in the field of science and technology. Nanomaterials are differing significantly from other materials due to their two major principal factors: the increased surface area and quantum effects. These factors can enhance properties such as reactivity, strength, electrical characteristics, and in vivo behavior. This article seeks to outline the role of nanotechnology in different areas such as imaging, diagnosis and management of diseases by an emerging nano device in the drug delivery system.Keywords
Nanotechnology, Nanoscience, Nanoparticles, Nanosponge, Carbon Nanotubes, Grapheme Smart Patch.- Synthesis of 3,4-Dihydro-1H-Pyrimidine-5-Carbohydrazide Derivatives and Their Pharmacological Screening
Abstract Views :170 |
PDF Views:0
Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Nagpur-441110, (MS), IN
2 RKDF College of Pharmacy, Bhopal (MP), IN
1 Sharad Pawar College of Pharmacy, Nagpur-441110, (MS), IN
2 RKDF College of Pharmacy, Bhopal (MP), IN